| | |  | | | | Record from Web of Science® | | | | | | |
| Early onset of reproductive function in normal female mice treated with leptin |
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| Author(s): Chehab FF, Mounzih K, Lu RH, Lim ME |
| Source: SCIENCE Volume: 275 Issue: 5296 Pages: 88-90 Published: JAN 3 1997 |
| Times Cited: 522 References: 11 |
| Abstract: Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chehab, FF (reprint author), UNIV CALIF SAN FRANCISCO, DEPT LAB MED, 505 PARNASSUS AVE, SAN FRANCISCO, CA 94143 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: WA903 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |