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| Vertical transmission of human immunodeficiency virus type 1: Seroreactivity by maternal antibodies to the carboxy region of the gp41 envelope glycoprotein |
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| Author(s): Ugen KE, Srikantan V, Goedert JJ, Nelson RP, Williams WV, Weiner DB |
| Source: JOURNAL OF INFECTIOUS DISEASES Volume: 175 Issue: 1 Pages: 63-69 Published: JAN 1997 |
| Times Cited: 22 References: 36 |
| Abstract: Maternal antibodies against the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) have previously been suggested to be important in influencing the rate of vertical transmission. In this study, serum antibody responses in mothers who did or did not transmit HIV-1 infection to their children were measured against the carboxy region of the transmembrane envelope glycoprotein gp41. Results indicate significantly higher binding reactivity of nontransmitter mothers compared with transmitters to three peptides spanning amino acids 771-810 and 841-856. In addition, high neutralization titers in maternal sera against HIV-1(MN) were associated with a nontransmission status. This is the initial report demonstrating a correlation between maternal antibody binding to epitopes within the carboxy region of gp41 envelope glycoprotein and lack of vertical transmission. Immunodetection that identifies antibodies to these regions in gp41 could therefore be considered a strategy to assess the risk of vertical transmission of HIV-1. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Ugen, KE (reprint author), UNIV S FLORIDA, COLL MED, DEPT MED MICROBIOL & IMMUNOL, MDC 10, 12901 BRUCE B DOWNS BLVD, TAMPA, FL 33612 USA |
Addresses:
1. UNIV S FLORIDA, COLL MED, ALL CHILDRENS HOSP, DEPT PEDIAT, ST PETERSBURG, FL USA
2. UNIFORMED SERV UNIV HLTH SCI, DEPT SURG, ROCKVILLE, MD USA
3. NCI, VIRAL EPIDEMIOL BRANCH, ROCKVILLE, MD USA
4. UNIV PENN, INST BIOTECHNOL & ADV MOL MED, DEPT MED, PHILADELPHIA, PA USA
5. UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Infectious Diseases |
| IDS Number: WA937 |
| ISSN: 0022-1899 |
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