| | |  | | | | Record from Web of Science® | | | | | | |
| Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs |
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| Author(s): Markram H, Lubke J, Frotscher M, Sakmann B |
| Source: SCIENCE Volume: 275 Issue: 5297 Pages: 213-215 Published: JAN 10 1997 |
| Times Cited: 1,113 References: 19 |
| Abstract: Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons. |
| Document Type: Article |
| Language: English |
Addresses:
1. MAX PLANCK INST MED RES, ZELLPHYSIOL ABT, D-69120 HEIDELBERG, GERMANY
2. UNIV FREIBURG, INST ANAT, D-79104 FREIBURG, GERMANY |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: WC022 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |