| | |  | | | | Record from Web of Science® | | | | | | |
| The world according to Hedgehog |
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| Author(s): Hammerschmidt M, Brook A, McMahon AP |
| Source: TRENDS IN GENETICS Volume: 13 Issue: 1 Pages: 14-21 Published: JAN 1997 |
| Times Cited: 383 References: 99 |
| Abstract: Members of the Hedgebog family of signaling molecules mediate many important short- and long-range patterning processes during invertebrate and vertebrate development. In the fly, a single hedgebog gene regulates segmental and imaginal disc patterning. In contrast, in vertebrates a hedgebog gene family is involved in the control of left-right asymmetry, polarity in the central nervous system (CNS), somites and limb, organogenesis, chondrogenesis and spermatogenesis. Here, we review experiments addressing the function of the various Hedgebog members during invertebrate and vertebrate development. |
| Document Type: Review |
| Language: English |
| Reprint Address: Hammerschmidt, M (reprint author), MAX PLANCK INST IMMUNBIOL, SPEMANN LABS, STUEBEWEG 51, D-79108 FREIBURG, GERMANY |
Addresses:
1. MASSACHUSETTS GEN HOSP, CTR CANC, MOL ONCOL LAB, CHARLESTOWN, MA 02129 USA
2. HARVARD UNIV, DEPT MOL & CELLULAR BIOL, BIOLABS, CAMBRIDGE, MA 02138 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: WC223 |
| ISSN: 0168-9525 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |