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| Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor |
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| Author(s): Winkler J, Ramirez GA, Kuhn HG, Peterson DA, DayLollini PA, Stewart GR, Tuszynski MH, Gage FH, Thal LJ |
| Source: ANNALS OF NEUROLOGY Volume: 41 Issue: 1 Pages: 82-93 Published: JAN 1997 |
| Times Cited: 64 References: 87 |
| Abstract: Substantial dysfunction and loss of cholinergic neurons occur in Alzheimer's disease (AD). Nerve growth factor (NGF) is a potent neurotrophic factor for cholinergic basal forebrain neurons, and the use of NGF to stimulate residual dysfunctional cells in AD is being considered. To define the effects of NGF on other cell populations in the brain, NGF was continuously infused into the lateral ventricle of rats for 7 weeks. At the end of treatment, Schwann cell hyperplasia and abundant sensory and sympathetic neurite sprouting were observed in the subpial region of the medulla oblongata and the spinal cord. Following withdrawal of NGF, the Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites disappeared completely. These findings suggest that better temporal and spatial delivery systems for NGF must be explored to limit potential undesirable side effects while maintaining the survival and function of diseased basal forebrain cholinergic neurons. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CALIF SAN DIEGO, DEPT NEUROSCI, SAN DIEGO, CA 92103 USA
2. VET AFFAIRS MED CTR, NEUROL SERV, SAN DIEGO, CA 92161 USA
3. SALK INST BIOL STUDIES, GENET LAB, LA JOLLA, CA USA
4. ROCHE BIOSCI, INST PHARMACOL, NEUROBIOL UNIT, PALO ALTO, CA USA |
| Publisher: LIPPINCOTT-RAVEN PUBL, 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 |
| Subject Category: Clinical Neurology; Neurosciences |
| IDS Number: WD974 |
| ISSN: 0364-5134 |
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