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| Expression of basic fibroblast growth factor and its mRNA in advanced uterine cervical cancers |
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| Author(s): Fujimoto J, Ichigo S, Hori M, Hirose R, Sakaguchi H, Tamaya T |
| Source: CANCER LETTERS Volume: 111 Issue: 1-2 Pages: 21-26 Published: JAN 1 1997 |
| Times Cited: 29 References: 32 |
| Abstract: To know the potential of growth, invasion and metastasis of uterine cervical cancer cells associated with neovascularization, the expression of basic fibroblast growth factor (FGF) and its mRNA in uterine cervical cancers and normal uterine cervices as controls were determined by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction-Southern blot (RT-PCR-SB), respectively. Then, the relations between the expression and the histological grading and clinical staging in cervical cancers were analyzed. The levels of basic FGF and its mRNA were significantly higher in advanced primary uterine cervical cancers, regardless of histological type. Therefore, this status might contribute to the acceleration of growth, invasion, and metastasis with neovascularization in advanced uterine cervical cancers. (C) 1997 Elsevier Science Ireland Ltd. All rights reserved |
| Document Type: Article |
| Language: English |
| Reprint Address: Fujimoto, J (reprint author), GIFU UNIV, SCH MED, DEPT OBSTET & GYNECOL, 40 TSUKASA MACHI, GIFU 500, JAPAN |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Oncology |
| IDS Number: WE076 |
| ISSN: 0304-3835 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |