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| Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma |
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| Author(s): Furutani M, Arii S, Tanaka H, Mise M, Niwano M, Harada T, Higashitsuji H, Imamura M, Fujita J |
| Source: CANCER LETTERS Volume: 111 Issue: 1-2 Pages: 191-197 Published: JAN 1 1997 |
| Times Cited: 22 References: 41 |
| Abstract: CIP1/WAF1, a critical downstream effector of tumor suppressor p53, encodes a cyclin-dependent kinase inhibitor. By Northern blot analysis, the CIP1/WAF1 mRNA level in the tumor was significantly lower than that in the corresponding normal liver from 19 Japanese patients with hepatocellular carcinoma P <0.05). In the tumor from only one; out of 19 patients (5%), somatic mutations of the CIP1/WAF1 as well as that of p53 gene were identified by RT-PCR/SSCP analysis. These results suggest that the decreased CIP1/WAF1 expression is involved in the carcinogenesis or the progression of hepatocellular carcinoma. (C) 1997 Elsevier Science Ireland Ltd. |
| Document Type: Article |
| Language: English |
| Reprint Address: Furutani, M (reprint author), KYOTO UNIV, DEPT SURG 1, SAKYO KU, 54 SHOGOIN KAWAHARA CHO, KYOTO 60601, JAPAN |
Addresses:
1. KYOTO UNIV, FAC MED, DEPT CLIN MOL BIOL, KYOTO 60601, JAPAN |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Oncology |
| IDS Number: WE076 |
| ISSN: 0304-3835 |
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