| | |  | | | | Record from Web of Science® | | | | | | |
| Quasiperiodicity and chaos in cardiac fibrillation |
|
|
| Author(s): Garfinkel A, Chen PS, Walter DO, Karagueuzian HS, Kogan B, Evans SJ, Karpoukhin M, Hwang C, Uchida T, Gotoh M, Nwasokwa O, Sager P, Weiss JN |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 99 Issue: 2 Pages: 305-314 Published: JAN 15 1997 |
| Times Cited: 103 References: 67 |
| Abstract: In cardiac fibrillation, disorganized waves of electrical activity meander through the heart, and coherent contractile function is lost. We studied fibrillation in three stationary forms: in human chronic atrial fibrillation, in a stabilized form of canine ventricular fibrillation, and in fibrillation-like activity in thin sheets of canine and human ventricular tissue in vitro. We also created a computer model of fibrillation. In all four studies, evidence indicated that fibrillation arose through a quasiperiodic stage of period and amplitude modulation, thus exemplifying the ''quasiperiodic transition to chaos'' first suggested by Ruelle and Takens. This suggests that fibrillation is a form of spatio-temporal chaos, a finding that implies new therapeutic approaches. |
| Document Type: Article |
| Language: English |
| Reprint Address: Garfinkel, A (reprint author), UNIV CALIF LOS ANGELES, SCH MED, DEPT MED CARDIOL, 47-123 CHS, LOS ANGELES, CA 90095 USA |
Addresses:
1. CEDARS SINAI MED CTR, DIV CARDIOL, LOS ANGELES, CA 90048 USA
2. W LOS ANGELES VET AFFAIRS MED CTR, LOS ANGELES, CA 90024 USA
3. UNIV CALIF LOS ANGELES, DEPT PHYSIOL SCI, LOS ANGELES, CA 90095 USA
4. UNIV CALIF LOS ANGELES, DEPT COMP SCI, LOS ANGELES, CA 90095 USA
5. LONG ISL JEWISH MED CTR, HARRIS CHASANOFF HEART INST, NEW HYDE PK, NY 11042 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: WE311 |
| ISSN: 0021-9738 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |