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| Association of BRCA1 with Rad51 in mitotic and meiotic cells |
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| Author(s): Scully R, Chen JJ, Plug A, Xiao YH, Weaver D, Feunteun J, Ashley T, Livingston DM |
| Source: CELL Volume: 88 Issue: 2 Pages: 265-275 Published: JAN 24 1997 |
| Times Cited: 935 References: 76 |
| Abstract: BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle. Human Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were found to colocalize in vivo and to coimmunoprecipitate. BRCA1 residues 758-1064 alone formed Rad51-containing complexes in vitro. Rad51 is also specifically associated with developing synaptonemal complexes in meiotic cells, and BRCA1 and Rad51 were both detected on asynapsed (axial) elements of human synaptonemal complexes. These findings suggest a functional interaction between BRCA1 and RadB1 in the meiotic and mitotic cell cycles, which, in turn, suggests a role for BRCA1 in the control of recombination and of genome integrity. |
| Document Type: Article |
| Language: English |
| Reprint Address: Scully, R (reprint author), HARVARD UNIV, SCH MED, DANA FARBER CANC INST, 44 BINNEY ST, BOSTON, MA 02115 USA |
Addresses:
1. YALE UNIV, SCH MED, DEPT GENET, NEW HAVEN, CT 06520 USA
2. INST GUSTAVE ROUSSY, CNRS, F-94805 VILLEJUIF, FRANCE |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: WE970 |
| ISSN: 0092-8674 |
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