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| Murine psoriasis-like disorder induced by naive CD4(+) T cells |
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| Author(s): Schon MP, Detmar M, Parker CM |
| Source: NATURE MEDICINE Volume: 3 Issue: 2 Pages: 183-188 Published: FEB 1997 |
| Times Cited: 97 References: 51 |
| Abstract: Psoriasis is a complex disorder involving alterations of many cell types. Although evidence suggests a T-cell pathogenesis for psoriasis, a primary role of T cells has not been directly demonstrated. Here, we show that reconstitution of scid/scid mice with minor histocompatibility mismatched naive CD4(+) T lymphocytes resulted in skin alterations that strikingly resembled human psoriasis clinically, histopathologically and in cytokine expression. This skin disorder was diminished when memory T cells were coinjected. Thus, a subset of dysregulated CD4(+) T cells can cause tissue alterations seen in psoriasis without the presence of CD8(+) cells or a primary epithelial abnormality. |
| Document Type: Article |
| Language: English |
| Reprint Address: Schon, MP (reprint author), BRIGHAM & WOMENS HOSP, DEPT RHEUMATOL & IMMUNOL, 250 LONGWOOD AVE, BOSTON, MA 02115 USA |
Addresses:
1. HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
2. BETH ISRAEL HOSP, DEPT PATHOL, BETH ISRAEL DEACONESS MED CTR, BOSTON, MA 02215 USA
3. BETH ISRAEL HOSP, DEPT DERMATOL, BETH ISRAEL DEACONESS MED CTR, BOSTON, MA 02215 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: WF088 |
| ISSN: 1078-8956 |
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