| | |  | | | | Record from Web of Science® | | | | | | |
| Expression of cell-cycle regulators p27(Kip1) and cyclin E, alone and in combination, correlate with survival in young breast cancer patients |
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| Author(s): Porter PL, Malone KE, Heagerty PJ, Alexander GM, Gatti LA, Firpo EJ, Daling JR, Roberts JM |
| Source: NATURE MEDICINE Volume: 3 Issue: 2 Pages: 222-225 Published: FEB 1997 |
| Times Cited: 682 References: 20 |
| Abstract: Mutations in certain genes that regulate the cell cycle, such as p16 and p53, are frequently found in human cancers(1). However, tumor-specific mutations are uncommon in genes encoding cyclin E and the CDK inhibitor p27(Kip1), two cell-cycle regulators that are also thought to contribute to tumor progression(2-8). It is now known that levels of both cyclin E and p27 can be controlled by posttranscriptional mechanisms, indicating that expression of these proteins can be altered by means other than simply mutation of their respective genes(9,10). Thus, changes in p27 and cyclin E protein levels in tumors might be more common than previously anticipated and may be indicators of tumor behavior. |
| Document Type: Article |
| Language: English |
| Reprint Address: Porter, PL (reprint author), FRED HUTCHINSON CANC RES CTR, PROGRAM CANC BIOL, C1-105, 1100 FAIRVIEW AVE N, SEATTLE, WA 98109 USA |
Addresses:
1. UNIV WASHINGTON, DIV PUBL HLTH SCI, PROGRAM EPIDEMIOL, SEATTLE, WA 98109 USA
2. UNIV WASHINGTON, DIV PUBL HLTH SCI, PROGRAM BIOSTAT, SEATTLE, WA 98109 USA
3. UNIV WASHINGTON, FRED HUTCHINSON CANC RES CTR, DIV BASIC SCI, SEATTLE, WA 98109 USA
4. UNIV WASHINGTON, SCH PUBL HLTH & COMMUNITY MED, DEPT BIOSTAT, SEATTLE, WA 98109 USA
5. UNIV WASHINGTON, SCH PUBL HLTH & COMMUNITY MED, DEPT PATHOL, SEATTLE, WA 98109 USA
6. UNIV WASHINGTON, SCH PUBL HLTH & COMMUNITY MED, DEPT EPIDEMIOL, SEATTLE, WA 98109 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: WF088 |
| ISSN: 1078-8956 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |