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| The origin of hepatitis C virus genotypes |
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| Author(s): Smith DB, Pathirana S, Davidson F, Lawlor E, Power J, Yap PL, Simmonds P |
| Source: JOURNAL OF GENERAL VIROLOGY Volume: 78 Pages: 321-328 Part: Part 2 Published: FEB 1997 |
| Times Cited: 128 References: 37 |
| Abstract: For many RNA viruses, relatively recent times of origin of extant viruses are implied by the high rate of substitution observed in longitudinal studies, However, extrapolation of short-term rates of substitution can give misleading estimates of times of divergence, We show here that the common ancestor of different types of hepatitis C virus (HCV) is older than previously thought, The rate of HCV sequence change was measured amongst a cohort of individuals infected following administration of anti-D immunoglobulin, Virus sequences were obtained in the E1 and NS5B genes and compared with each other and with sequences from an infective batch, Taking account of the bias towards synonymous transition substitutions, the time of divergence of variants of subtype 1b is estimated to have occurred 70-80 years ago, The numerous subtypes of HCV are proposed to derive from more than 300 years of endemic infection in certain geographical regions, with recent spread of some subtypes to other parts of the world, Estimation of the time of origin of the major HCV genotypes (types 1-6) is problematic, but our data and analogy with other viruses suggest that divergence occurred at least 500-2000 years ago. |
| Document Type: Article |
| Language: English |
| Reprint Address: Smith, DB (reprint author), UNIV EDINBURGH, SCH MED, DEPT MED MICROBIOL, TEVIOT PL, EDINBURGH EH8 9AG, MIDLOTHIAN SCOTLAND |
Addresses:
1. EDINBURGH & SE SCOTLAND BLOOD TRANSFUS SERV, EDINBURGH EH3 9HB, MIDLOTHIAN SCOTLAND
2. IRISH BLOOD TRANSFUS SERV BOARD, DUBLIN, IRELAND
3. ST FINBARRS HOSP, CORK, IRELAND |
| Publisher: SOC GENERAL MICROBIOLOGY, MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING, BERKS, ENGLAND RG7 1AE |
| Subject Category: Biotechnology & Applied Microbiology; Virology |
| IDS Number: WF422 |
| ISSN: 0022-1317 |
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