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| Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked |
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| Author(s): Yang J, Liu XS, Bhalla K, Kim CN, Ibrado AM, Cai JY, Peng TI, Jones DP, Wang XD |
| Source: SCIENCE Volume: 275 Issue: 5303 Pages: 1129-1132 Published: FEB 21 1997 |
| Times Cited: 2,741 References: 37 |
| Abstract: Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV TEXAS, SW MED CTR, DEPT BIOCHEM, DALLAS, TX 75235 USA
2. EMORY UNIV, SCH MED, DEPT BIOCHEM, ATLANTA, GA 30322 USA
3. EMORY UNIV, SCH MED, WINSHIP CANC CTR, DEPT MED, DIV HEMATOL ONCOL, ATLANTA, GA 30322 USA
4. EMORY UNIV, SCH MED, DEPT NEUROL, ATLANTA, GA 30322 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: WJ503 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |