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| HECA-452(+) T cells migrate through superficial vascular plexus but not through deep vascular plexus endothelium |
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| Author(s): Kunstfeld R, Lechleitner S, Groger M, Wolff K, Petzelbauer P |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 108 Issue: 3 Pages: 343-348 Published: MAR 1997 |
| Times Cited: 21 References: 29 |
| Abstract: The skin is nourished by two interconnected vascular systems, the superficial vascular plexus coursing just beneath the epidermis and the deep vascular plexus located above the subcutaneous tissue. Skin inflammatory T cells in diseases, such as psoriasis or dermatitis, strikingly aim for the superficial vascular plexus without involving the deep vascular plexus, and the infiltrating T cells bear a distinct phenotype expressing the cutaneous lymphocyte-associated antigen, which is recognized by mAb HECA-452, We wanted to know whether HECA-452(+) lymphocytes indeed are able to distinguish between superficial and deep vascular plexus homing sites, Employing the hu-SCID mouse model grafted with human skin and human T cells, as described previously, we developed a new skin-grafting strategy providing superficial and deep vascular plexus skin specimens placed separately onto the same mouse. Fourteen days after allogeneic human T cell grafting, both human skin sites were densely infiltrated by human T cells, but only T cells within the superficial vascular plexus, but not within the deep vascular plexus, expressed the cutaneous lymphocyte-associated antigen. IL-2 and IFN-gamma expression and allogeneic vessel destruction were present within both superficial and deep vascular plexus skin, This model provides direct evidence that expression of a specific homing receptor is indeed able to direct lymphocyte traffic, not only to a distinct organ but also to a distinct vascular bed within one organ. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV VIENNA, SCH MED, DEPT DERMATOL, A-1090 VIENNA, AUSTRIA |
| Publisher: BLACKWELL SCIENCE INC, 350 MAIN ST, MALDEN, MA 02148 |
| Subject Category: Dermatology |
| IDS Number: WJ663 |
| ISSN: 0022-202X |
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