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| Microsatellite instability in cervical and endometrial carcinomas |
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| Author(s): Helland A, BorresenDale AL, Peltomaki P, Hektoen M, Kristensen GB, Nesland JM, delaChapelle A, Lothe RA |
| Source: INTERNATIONAL JOURNAL OF CANCER Volume: 70 Issue: 5 Pages: 499-501 Published: MAR 4 1997 |
| Times Cited: 56 References: 27 |
| Abstract: Microsatellite instability has been found preferentially in tumours associated with the hereditary non-polyposis-colorectal cancer (HNPCC) syndrome, This phenotype, manifested as new alleles at microsatellite loci, and often the result of a defective mismatch-repair gene, is seen as allelic mobility shifts during electrophoretic runs. We examined possible alterations at 8 dinucleotide loci mapping to 6 different chromosomes in endometrial cancers (n = 20) and cervical cancers (n = 82). Overall instability was found in 30% of the endometrial cancers and in 6% of the cervical cancers, including 3 (15%) and 2 (2%) tumours, respectively, unstable at more than one locus. In contrast to the endometrial cancer sub-group, the affected cervical cancers were characterized by one or two new alleles at one or few loci, By DNA ploidy measurements 5 diploid endometrial cancers were microsatellite-unstable vs. one diploid of 6 unaltered cases (p = 0.015; Fisher's exact test). Our data confirm that a sub-set of diploid sporadic endometrial cancers are characterized by a mutator phenotype similar to that found in colorectal cancer, In contrast, among cervical cancers, not characterized by the HNPCC-tumour spectrum, this mutator phenotype is seen infrequently, and positive cases appear to display only minor alterations. (C) 1997 Wiley-Liss, inc. |
| Document Type: Article |
| Language: English |
Addresses:
1. NORWEGIAN RADIUM HOSP, INST CANC RES, DEPT GENET, N-0310 OSLO, NORWAY
2. NORWEGIAN RADIUM HOSP, DEPT GYNECOL, N-0310 OSLO, NORWAY
3. NORWEGIAN RADIUM HOSP, DEPT PATHOL, N-0310 OSLO, NORWAY
4. UNIV HELSINKI, DEPT MED GENET, SF-00014 HELSINKI, FINLAND |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology |
| IDS Number: WK579 |
| ISSN: 0020-7136 |
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