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| Comparative genomic hybridization study of primary neuroblastoma tumors |
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| Author(s): Lastowska M, Nacheva E, McGuckin A, Curtis A, Grace C, Pearson A, Bown N |
| Source: GENES CHROMOSOMES & CANCER Volume: 18 Issue: 3 Pages: 162-169 Published: MAR 1997 |
| Times Cited: 78 References: 30 |
| Abstract: Neuroblastoma tumors show a complex interaction of genetic abnormalities, among which some are of significant prognostic importance; however, analysis of chromosome changes in this tumor is often unsuccessful. Twenty primary tumors were studied by comparative genomic hybridization (CGH), and abnormalities were found in 19. While these changes included deletions of chromosome arm 1p (45%) and MYCN oncogene amplification (30%), gains of chromosome 17 material were much more frequent (75%). We also found evidence in two cases of a new amplification site at band 2p23. (C) 1997 Wiley-Liss, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: Lastowska, M (reprint author), UNIV NEWCASTLE, DEPT HUMAN GENET, 19-20 CLAREMONT PL, NEWCASTLE UPON TYNE NE2 4AA, TYNE & WEAR ENGLAND |
Addresses:
1. UNIV NEWCASTLE, DEPT CHILD HLTH, NEWCASTLE UPON TYNE NE2 4AA, TYNE & WEAR ENGLAND
2. UNIV NEWCASTLE, CANC RES UNIT, NEWCASTLE UPON TYNE NE2 4AA, TYNE & WEAR ENGLAND
3. UNIV CAMBRIDGE, ADDENBROOKES HOSP, DEPT HAEMATOL, CAMBRIDGE CB2 1TN, ENGLAND
4. ROYAL VICTORIA INFIRM, DEPT PATHOL, NEWCASTLE UPON TYNE NE1 4LP, TYNE & WEAR ENGLAND
5. DIGITAL SCI LTD, CAMBRIDGE, ENGLAND
6. INST PAEDIAT, CLIN PAEDIAT HAEMATOL & ONCOL, POZNAN, POLAND |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology; Genetics & Heredity |
| IDS Number: WM741 |
| ISSN: 1045-2257 |
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