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| The cellular and molecular response of cardiac myocytes to mechanical stress |
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| Author(s): Sadoshima J, Izumo S |
| Source: ANNUAL REVIEW OF PHYSIOLOGY Volume: 59 Pages: 551-571 Published: 1997 |
| Times Cited: 451 References: 112 |
| Abstract: External load plays a critical role in determining muscle mass and its phenotype in cardiac myocytes. Cardiac myocytes have the ability to sense mechanical stretch and convert it into intracellular growth signals, which lead to hypertrophy. Mechanical stretch of cardiac myocytes in vitro causes activation of multiple second messenger systems that are very similar to growth factor-induced cell signaling systems. Stretch of neonatal rat cardiac myocytes stimulates a rapid secretion of angiotensin II which, together with other growth factors, mediates stretch-induced hypertrophic responses in vitro. In this review, various cell signaling mechanisms initiated by mechanical stress on cardiac myocytes are summarized with emphasis on potential mechanosensing mechanisms and the relationship between mechanical loading and the cardiac renin-angiotensin system. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sadoshima, J (reprint author), UNIV MICHIGAN, MED CTR, DIV CARDIOL, CARDIOVASC RES CTR, ANN ARBOR, MI 48109 USA |
| Publisher: ANNUAL REVIEWS INC, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 |
| Subject Category: Physiology |
| IDS Number: WM922 |
| ISSN: 0066-4278 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |