| | |  | | | | Record from Web of Science® | | | | | | |
| Stabilization of beta-catenin by genetic defects in melanoma cell lines |
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| Author(s): Rubinfeld B, Robbins P, ElGamil M, Albert I, Porfiri E, Polakis P |
| Source: SCIENCE Volume: 275 Issue: 5307 Pages: 1790-1792 Published: MAR 21 1997 |
| Times Cited: 838 References: 22 |
| Abstract: Signal transduction by beta-catenin involves its posttranslational stabilization and downstream coupling to the Lef and Tcf transcription factors, Abnormally high amounts of beta-catenin were detected in 7 of 26 human melanoma cell lines, Unusual messenger RNA splicing and missense mutations in the beta-catenin gene (CTNNB1) that result in stabilization of the protein were identified in six of the lines, and the adenomatous polyposis coli tumor suppressor protein (APC) was altered or missing in two others, In the APC-deficient cells, ectopic expression of wild-type APC eliminated the excess beta-catenin, Cells with stabilized beta-catenin contained a constitutive beta-catenin-Lef-1 complex, Thus, genetic defects that result in up-regulation of beta-catenin may play a role in melanoma progression. |
| Document Type: Article |
| Language: English |
Addresses:
1. ONYX PHARMACEUT, RICHMOND, CA 94806 USA
2. NCI, SURG BRANCH, NIH, BETHESDA, MD 20892 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: WP056 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |