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| 1,25-Dihydroxyvitamin D-3 and 9-cis-retinoic acid act synergistically to inhibit the growth of LNCaP prostate cells and cause accumulation of cells in G(1) |
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| Author(s): Blutt SE, Allegretto EA, Pike JW, Weigel NL |
| Source: ENDOCRINOLOGY Volume: 138 Issue: 4 Pages: 1491-1497 Published: APR 1997 |
| Times Cited: 155 References: 31 |
| Abstract: Recent studies have suggested that the active metabolite of vitamin D-3, 1,25-dihydroxyvitamin D-3, can inhibit the growth and/or induce the differentiation of a variety of cell types and that these characteristics might be useful in the treatment of some cancers. Retinoids also promote the differentiation and inhibit the growth of some cells. That the vitamin D receptor acts as a heterodimer with the retinoid X receptor (RXR) suggests that there may be functional interactions between 1,25-dihydroxyvitamin D, and retinoids. In this study, we show that the combination of 1,25-dihydroxyvitamin D, and 9-cis retinoic acid synergistically inhibits the growth of LNCaP prostate cancer cells. That this effect is mediated by RXR rather than retinoic acid receptors was shown using RXR- and retinoic acid receptor-specific ligands. The vitamin D, analog, EB1089, inhibited growth more effectively than 1,25-dihydroxyvitamin D, and also acted synergistically with B-cis-retinoic acid. These treatments caused cells to accumulate in the G(1) phase of the cell cycle, suggesting that 1,25dihydroxyvitamin D, can regulate one or more factors critical for the G(1)/S transition. |
| Document Type: Article |
| Language: English |
Addresses:
1. BAYLOR COLL MED, DEPT CELL BIOL, HOUSTON, TX 77030 USA
2. LIGAND PHARMACEUT INC, SAN DIEGO, CA 92121 USA
3. UNIV CINCINNATI, DEPT MOL & CELLULAR PHYSIOL, CINCINNATI, OH 45267 USA |
| Publisher: ENDOCRINE SOC, 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: WP335 |
| ISSN: 0013-7227 |
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