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| A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis |
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| Author(s): Helbing CC, Veillette C, Riabowol K, Johnston RN, Garkavtsev I |
| Source: CANCER RESEARCH Volume: 57 Issue: 7 Pages: 1255-1258 Published: APR 1 1997 |
| Times Cited: 108 References: 21 |
| Abstract: We have recently cloned a novel growth inhibitor and candidate tumor suppressor called p33(ING1) (I. Garkavtsev et al., Nature Genet,, 14: 415-420, 1996), Because some tumor suppressors participate in the regulation of apoptosis, we hypothesized that the ING1 gene may also play a role in this process, Our results show that p33(ING1) levels increase upon the induction of apoptosis in P19 teratocarcinoma cells by serum deprivation, Elevated expression of ING1 in P19 and rodent fibroblast cells containing a tetracycline-controlled human c-myc gene enhanced the extent of serum starvation-induced apoptosis, This suggests that the pathway by which ING1 modulates cell death is synergistic with Myc-dependent apoptosis, Conversely, constitutive expression of an antisense construct of ING1 conferred protection against apoptosis in these cells, These data support the idea that loss of proper ING1 function may facilitate tumorigenesis, in part, by reducing the cell's sensitivity to apoptosis. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CALGARY, DEPT MED BIOCHEM, CALGARY, AB T2N 4N1 CANADA
2. UNIV CALGARY, SO ALBERTA CANC RES CTR, CALGARY, AB T2N 4N1 CANADA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: WQ625 |
| ISSN: 0008-5472 |
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