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| Hypermethylation of the APC (adenomatous Polyposis coli) gene promoter region in human colorectal carcinoma |
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| Author(s): Hiltunen MO, Alhonen L, Koistinaho J, Myohanen S, Paakkonen M, Marin S, Kosma VM, Janne J |
| Source: INTERNATIONAL JOURNAL OF CANCER Volume: 70 Issue: 6 Pages: 644-648 Published: MAR 17 1997 |
| Times Cited: 117 References: 16 |
| Abstract: Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia, Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma or adenoma, the APC gene was mutated, By employing genomic sequencing, i.e., base-specific analysis of methylated cytosines, we show here that the promoter region of the APC gene is heavily methylated at CpG sites in patients with colorectal carcinoma in comparison with normal colonic mucosa and premalignant adenomas, Our results suggest that cytosine methylation of the regulatory sequences of the APC gene could be involved in the progression of human colorectal cancer. (C) 1997 Wiley-Liss, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hiltunen, MO (reprint author), UNIV KUOPIO, VIRTANEN INST, POB 1627, FIN-70211 KUOPIO, FINLAND |
Addresses:
1. KUOPIO UNIV HOSP, DEPT SURG, SF-70210 KUOPIO, FINLAND
2. KUOPIO UNIV HOSP, DEPT PATHOL, SF-70210 KUOPIO, FINLAND
3. KUOPIO UNIV HOSP, DEPT PATHOL & FORENS MED, SF-70210 KUOPIO, FINLAND |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology |
| IDS Number: WQ886 |
| ISSN: 0020-7136 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |