| | |  | | | | Record from Web of Science® | | | | | | |
| Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation |
|
|
| Author(s): Baramova EN, Bajou K, Remacle A, LHoir C, Krell HW, Weidle UH, Noel A, Foidart JM |
| Source: FEBS LETTERS Volume: 405 Issue: 2 Pages: 157-162 Published: MAR 24 1997 |
| Times Cited: 159 References: 35 |
| Abstract: Pro-MMP2 activation is a two-step process resulting in (1) an intermediate 64 kDa form generated by the MT1-MMP activity, and (2) a mature 62 kDa form. Addition of plasminogen to HT1080 cells cultured under various conditions, or to their membrane preparation, induced a complete conversion of the intermediate MMP-2 form to the mature one, and processing of pro-MMP-9. The pro-MMP-2 activation was inhibited by plasmin inhibitors and anti-uPA antibody. These results provide evidence for involvement of the PA/plasmin system in the second step of MMP-2 activation. (C) 1997 Federation of European Biochemical Societies. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV LIEGE, BIOL LAB, B-4000 LIEGE, BELGIUM
2. BOEHRINGER MANNHEIM GMBH, PENZBERG, GERMANY |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: WR212 |
| ISSN: 0014-5793 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |