| | |  | | | | Record from Web of Science® | | | | | | |
| Diagnostic and prognostic value of Cyfra 21-1 compared with other tumour markers in patients with non-small cell lung cancer: A prospective study of 116 patients |
|
|
| Author(s): Brechot JM, Chevret S, Nataf J, LeGall C, Fretault J, Rochemaure J, Chastang C |
| Source: EUROPEAN JOURNAL OF CANCER Volume: 33 Issue: 3 Pages: 385-391 Published: MAR 1997 |
| Times Cited: 40 References: 27 |
| Abstract: The diagnostic value of Cyfra 21-1 in non-small lung cancer (NSCLC) has been established, but few studies have focused on its prognostic value. The aim of this study was to compare that of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA 125, neuron-specific enolase and squamous cell carcinoma antigen. 116 patients with unresectable (n = 88) or resectable (n = 28) NSCLC were prospectively monitored from diagnosis, for a median of 14.4 months. All; patients underwent tumour-marker determinations before treatment, then every 3 months. Their diagnostic value was studied using ROC (receiver operating characteristic) curves, based on control measure in 23 patients with benign lung diseases. The prognostic analysis was based on overall survival as the main endpoint. The diagnostic value of Cyfra 21-1 was confirmed, with a sensitivity of 54% and a specificity of 96% at a cut-off value of 3.3 ng/ml. At diagnosis, in the 88 non-surgical NSCLC, besides the presence of metastases (P = 0.017), Cyfra 21-1 (P = 0.017) and CA 125 (P = 0.03) were related to outcome. Elevated levels of Cyfra 21-1 at any time during the disease course was selected by multivariate analysis as additional predictors of poor survival. (C) 1997 Elsevier Science Ltd. |
| Document Type: Article |
| Language: English |
| Reprint Address: Brechot, JM (reprint author), HOP HOTEL DIEU, SERV PNEUMOL, 1 PL PARVIS NOTRE DAME, F-75181 PARIS 04, FRANCE |
Addresses:
1. HOP ST LOUIS, DEPT BIOSTAT & INFORMAT MED, F-75475 PARIS 10, FRANCE
2. HOP HOTEL DIEU, BIOPHYS LAB, F-75181 PARIS 04, FRANCE |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB |
| Subject Category: Oncology |
| IDS Number: WR551 |
| ISSN: 0959-8049 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |