| Bik and bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis |
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| Author(s): Orth R, Dixit VM |
| Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 272 Issue: 14 Pages: 8841-8844 Published: APR 4 1997 |
| Times Cited: 12 References: 51 |
| Abstract: Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV MICHIGAN, SCH MED, DEPT PATHOL, ANN ARBOR, MI 48109 USA |
| Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: WU037 |
| ISSN: 0021-9258 |