| | |  | | | | Record from Web of Science® | | | | | | |
| Integrated clinical experience with tolerogenic peptides |
|
|
| Author(s): Nicodemus C, Philip G, Jones N, Hirani S, Norman P |
| Source: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY Volume: 113 Issue: 1-3 Pages: 326-328 Published: 1997 |
| Times Cited: 14 References: 7 |
| Abstract: More than 2,000 patients have been dosed in the clinical development programs for Allervax(R) Cat and Ragweed products in North America, Europe and Japan. Two peptides derived from Fel d 1 and three peptides derived from Amb a 1 were selected for clinical development following T cell epitope mapping of these major allergens. Clinical activity has been demonstrated in several dose regimens containing 75 and 750 mu g of each component peptide given in 3-6 doses over 2-1 weeks. Greater activity has been seen with higher doses. Immediate hypersensitivity to treatment peptides is rarely seen and can be avoided through patient screening. A putative pathway resulting in histamine-mediated but IgE-independent allergic symptoms, similar in nature and severity to natural allergen exposure, has been identified in association with treatment. These manifestations are more pronounced in cat than ragweed allergy and are consistent with the respective diseases. When desired, the symptoms may be ameliorated with administration of H-1 blockers prior to symptom appearance. The seasonal rise in allergen-specific IgE is blunted in association with therapy. Antigen-specific antibody levels (IgE and IgG), T cell primary proliferation and immediate skin test sensitivity will be followed in longer-term studies. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Nicodemus, C (reprint author), IMMULOG PHARMACEUT CORP, 610 LINCOLN ST, WALTHAM, MA 02154 USA |
Addresses:
1. JOHNS HOPKINS UNIV, SCH MED, JOHNS HOPKINS ASTHMA & ALLERGY CTR, BALTIMORE, MD USA |
| Publisher: KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND |
| Subject Category: Allergy; Immunology |
| IDS Number: WV647 |
| ISSN: 1018-2438 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |