| | |  | | | | Record from Web of Science® | | | | | | |
| Differential activation of transcription factors induced by Ca2+ response amplitude and duration |
|
|
| Author(s): Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI |
| Source: NATURE Volume: 386 Issue: 6627 Pages: 855-858 Published: APR 24 1997 |
| Times Cited: 950 References: 30 |
| Abstract: An increase in the intracellular calcium ion concentration ([Ca2+](i)) controls a diverse range of cell functions, including adhesion, motility, gene expression and proliferation(1,2). Calcium signalling patterns can occur as single transients, repetitive oscillations or sustained plateaux(2,3), but it is not known whether these patterns are responsible for encoding the specificity of cellular responses. We report here that the amplitude and duration of calcium signals in B lymphocytes controls differential activation of the pro-inflammatory transcriptional regulators NF-kappa B, c-Jun N-terminal kinase (JNK) and NFAT. NF-kappa B and JNK are selectively activated by a large transient [Ca2+](i) rise, whereas NFAT is activated by a low sustained Ca2+ plateau. Differential activation results from differences in the Ca2+ sensitivities and kinetic behaviour of the three pathways. Our results show how downstream effecters can decode information contained in the amplitude and duration of Ca2+ signals, revealing a mechanism by which a multifunctional second messenger such as Ca2+ can achieve specificity in signalling to the nucleus. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, SCH MED, DEPT CELLULAR & MOL PHYSIOL, STANFORD, CA 94305 USA
2. STANFORD UNIV, SCH MED, NEUROSCI PROGRAM, STANFORD, CA 94305 USA
3. STANFORD UNIV, SCH MED, PROGRAM IMMUNOL, STANFORD, CA 94305 USA
4. STANFORD UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, STANFORD, CA 94305 USA
5. STANFORD UNIV, SCH MED, HOWARD HUGHES MED INST, STANFORD, CA 94305 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: WV706 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |