| | |  | | | | Record from Web of Science® | | | | | | |
| An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis |
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| Author(s): Choudhuri R, Zhang HT, Donnini S, Ziche M, Bicknell R |
| Source: CANCER RESEARCH Volume: 57 Issue: 9 Pages: 1814-1819 Published: MAY 1 1997 |
| Times Cited: 155 References: 28 |
| Abstract: Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in tumorigenesis, they mere overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular density and endothelial proliferation, implicating an angiogenic role for MK and PTN. Angiogenic activity of MK and PTN was confirmed in the rabbit corneal assay. Our data therefore identify two novel targets for antiangiogenic drug development. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV OXFORD, JOHN RADCLIFFE HOSP, IMPERIAL CANC RES FUND, INST MOL MED, MOL ANGIOGENESIS GRP, OXFORD OX3 9DU, ENGLAND
2. UNIV FLORENCE, DEPT PHARMACOL, I-50134 FLORENCE, ITALY |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: WW569 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |