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| HIP1, a human homologue of S-cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain |
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| Author(s): Kalchman MA, Koide HB, McCutcheon K, Graham RK, Nichol K, Nishiyama K, KazemiEsfarjani P, Lynn FC, Wellington C, Metzler M, Goldberg YP, Kanazawa I, Gietz RD, Hayden MR |
| Source: NATURE GENETICS Volume: 16 Issue: 1 Pages: 44-53 Published: MAY 1997 |
| Times Cited: 241 References: 49 |
| Abstract: Huntington disease (HD) is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. Here we describe a novel huntingtin interacting protein, HIP1, which co-localizes with huntingtin and shares sequence homology and biochemical characteristics with Sla2p, a protein essential for function of the cytoskeleton in Saccharomyces cerevisiae. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in huntingtin. This provides the first molecular link between huntingtin and the neuronal cytoskeleton and suggests that, in HD, loss of normal huntingtin-HIP1 interaction may contribute to a defect in membrane-cytoskeletal integrity in the brain. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC V6T 1Z4 CANADA
2. UNIV TOKYO, FAC MED, DEPT CLIN NEUROL & NEUROSCI, TOKYO 113, JAPAN
3. UNIV MANITOBA, FAC MED, DEPT HUMAN GENET, WINNIPEG, MB R3E 0W3 CANADA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: WX024 |
| ISSN: 1061-4036 |
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