| | |  | | | | Record from Web of Science® | | | | | | |
| Factors controlling the turnover of T memory cells |
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| Author(s): Sprent J, Tough DF, Sun SQ |
| Source: IMMUNOLOGICAL REVIEWS Volume: 156 Pages: 79-85 Published: APR 1997 |
| Times Cited: 67 References: 57 |
| Abstract: Most of the T cells participating in the primary immune response are rapidly eliminated, but small numbers of these cells survive and differentiate into long-lived memory cells. Information on the life history of memory cells can be obtained by studying the component of memory-phenotype T cells found in normal animals; these cells are presumed to represent memory cells specific for various environmental antigens. For CD8(+) cells, in vivo exposure to viruses and certain other infectious agents causes a large proportion of memory-phenotype (CD44(hi)) cells to enter the cell cycle. In this situation, stimulation of CD44(hi) CD8(+) cells does not seem to require T-cell receptor ligation and appears to reflect release of various cytokines, especially type I interferon. The capacity of infectious agents to induce non-antigen-specific stimulation of T cells may play a role in boosting the survival of memory cells and perhaps also in providing an adjuvant function during the primary response. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sprent, J (reprint author), Scripps Res Inst, DEPT IMMUNOL, IMM4, 10550 N TORREY PINES RD, LA JOLLA, CA 92037 USA |
| Publisher: MUNKSGAARD INT PUBL LTD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK |
| Subject Category: Immunology |
| IDS Number: WY221 |
| ISSN: 0105-2896 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |