| Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats |
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| Author(s): Longo BM, Mello LEAM |
| Source: NEUROSCIENCE LETTERS Volume: 226 Issue: 3 Pages: 163-166 Published: MAY 2 1997 |
| Times Cited: 102 References: 25 |
| Abstract: Post-injury sprouting of hippocampal messy fibers has been suggested to be a causal mechanism underlying the development of temporal lobe epilepsy. However, this hypothesis rests entirely on indirect correlational evidence. Here we demonstrate that cycloheximide, a protein synthesis inhibitor, blocked pilocarpine- and kainate-induced messy fiber sprouting in rats, bur did not prevent the subsequent development of spontaneous seizures or affect their frequency. These results provide direct evidence against a causal role for messy fiber sprouting in temporal lobe epileptogenesis. (C) 1997 Elsevier Science Ireland Ltd. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV FED SAO PAULO, EPM, DEPT PHYSIOL, BR-04023900 SAO PAULO, BRAZIL |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Neurosciences |
| IDS Number: WY622 |
| ISSN: 0304-3940 |