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| The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum |
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| Author(s): Ouyang H, Shiwaku HO, Hagiwara H, Miura K, Abe T, Kato Y, Ohtani H, Shiiba K, Souza RF, Meltzer SJ, Horii A |
| Source: CANCER RESEARCH Volume: 57 Issue: 10 Pages: 1851-1854 Published: MAY 15 1997 |
| Times Cited: 148 References: 33 |
| Abstract: Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MI), plays an important role in the course of human carcinogenesis. Repetitive sequences constitute targets for mutation in MI+ cells, and frequent mutations have indeed been reported in such regions within the transforming growth factor beta receptor II (RII) gene in genetically unstable colorectal and gastric cancers, However, other genes that are targets for mutations in MI+ cells during the course of carcinogenesis have proven elusive. Because the insulin-like growth factor II receptor (IGFIIR) gene contains several repetitive sequences within its coding region, we examined mutations of this gene in MI+ cancers occurring at various primary sites. We found frameshift mutations in the poly(G)(8) tract of IGFIIR in eight tumors, all of which were MI+: 4 of 26 (15%) MI+ endometrial cancers, 3 of 12 (25%) MI+ gastric cancers, and 1 of 18 (6%) MI+ colorectal cancers. In contrast, no mutation was found in 51 pancreatic cancers, 7 of which (14%) were MI+. These results implicate abnormal IGFIIR-mediated growth control in carcinogenesis involving the endometrium, stomach, and colorectum but not the pancreas. |
| Document Type: Article |
| Language: English |
Addresses:
1. TOHOKU UNIV, SCH MED, DEPT MOL PATHOL, SENDAI, MIYAGI 98077 JAPAN
2. TOHOKU UNIV, SCH MED, DEPT PATHOL, SENDAI, MIYAGI 98077 JAPAN
3. TOHOKU UNIV, SCH MED, DEPT SURG, SENDAI, MIYAGI 98077 JAPAN
4. HITACHI ELECT ENGN CO LTD, SHIBUYA KU, TOKYO 150, JAPAN
5. JAPANESE FDN CANC RES, INST CANC, DEPT PATHOL, TOSHIMA KU, TOKYO 170, JAPAN
6. UNIV MARYLAND, SCH MED, DEPT MED, GASTROINTESTINAL DIV, BALTIMORE, MD 21201 USA
7. BALTIMORE VET AFFAIRS MED CTR, BALTIMORE, MD 21201 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: WZ216 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |