| | |  | | | | Record from Web of Science® | | | | | | |
| Gene expression profiles in normal and cancer cells |
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| Author(s): Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B, Kinzler KW |
| Source: SCIENCE Volume: 276 Issue: 5316 Pages: 1268-1272 Published: MAY 23 1997 |
| Times Cited: 922 References: 34 |
| Abstract: As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers. |
| Document Type: Article |
| Language: English |
Addresses:
1. JOHNS HOPKINS UNIV, SCH MED, CTR ONCOL, HOWARD HUGHES MED INST, BALTIMORE, MD 21231 USA
2. JOHNS HOPKINS UNIV, SCH MED, PROGRAM HUMAN GENET & MOL BIOL, BALTIMORE, MD 21231 USA
3. JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21231 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XA497 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |