| | |  | | | | Record from Web of Science® | | | | | | |
| Mammalian RNA-dependent deaminases and edited mRNAs |
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| Author(s): Maas S, Melcher T, Seeburg PH |
| Source: CURRENT OPINION IN CELL BIOLOGY Volume: 9 Issue: 3 Pages: 343-349 Published: JUN 1997 |
| Times Cited: 51 References: 49 |
| Abstract: The past year has witnessed major progress in the field of mammalian nuclear RNA editing. Two new sequence-related RNA-dependent adenosine deaminases, distantly related to the previously characterized double-stranded RNA adenosine deaminase DRADA/dsRAD, have been molecularly characterized. One of these deaminases edits in vitro with precision for the molecular determinant that controls the Ca2+ permeability of fast synaptic glutamate-gated cation channels. This deaminase, like DRADA, is expressed in many tissues and the search is now on for more substrates of these RNA-editing enzymes. Moreover, the physiological role of the apolipoprotein B RNA editing enzyme APOBEC-1 has been investigated in genetically manipulated mice. |
| Document Type: Article |
| Language: English |
| Reprint Address: Maas, S (reprint author), MAX PLANCK INST MED RES, DEPT MOL NEUROBIOL, JAHNSTR 29, D-69120 HEIDELBERG, GERMANY |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Cell Biology |
| IDS Number: XC153 |
| ISSN: 0955-0674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |