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| Paraneoplastic cerebellar degeneration - Case report and literature review |
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| Author(s): Bolla L, Palmer RM |
| Source: ARCHIVES OF INTERNAL MEDICINE Volume: 157 Issue: 11 Pages: 1258-1262 Published: JUN 9 1997 |
| Times Cited: 13 References: 33 |
| Abstract: Paraneoplastic cerebellar degeneration (PCD) presents with acute or subacute onset of ataxial dysarthria, and intention tremor. In patients older than 50 years, acute or subacute cerebellar degeneration is paraneoplastic in origin in 50% of cases. Paraneoplastic cerebellar degeneration most often precedes a potentially curable remote malignancy. less often, PCD occurs in a patient with a known malignancy or heralds the onset of a recurrence. The presence of specific antibodies in serum samples helps to guide identification of the occult underlying malignancy. Physicians should entertain the diagnosis of PCD when older patients present with signs of cerebellar degeneration without an obvious cause. A systematic evaluation, including the selection of appropriate imaging and laboratory studies, will often enable physicians to identify the responsible cancer. However, because PCD can precede a cancer by months to years, periodic reevaluation is needed when the cancer remains occult. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Bolla, L (reprint author), CLEVELAND CLIN FDN, GERIATR MED SECT, 9500 EUCLID AVE, CLEVELAND, OH 44195 USA |
| Publisher: AMER MEDICAL ASSOC, 515 N STATE ST, CHICAGO, IL 60610 |
| Subject Category: Medicine, General & Internal |
| IDS Number: XC812 |
| ISSN: 0003-9926 |
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