| | |  | | | | Record from Web of Science® | | | | | | |
| K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons |
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| Author(s): Hoffman DA, Magee JC, Colbert CM, Johnston D |
| Source: NATURE Volume: 387 Issue: 6636 Pages: 869-875 Published: JUN 26 1997 |
| Times Cited: 595 References: 44 |
| Abstract: Pyramidal neurons receive tens of thousands of synaptic inputs on their dendrites. The dendrites dynamically after the strengths of these synapses and coordinate them to produce an output in ways that are not well understood. surprisingly, there turns out to be a very high density of transient A-type potassium ion channels in dendrites of hippocampal CA1 pyramidal neurons. These channels prevent initiation of an action potential in the dendrites, limit the back-propagation of action potentials into the dendrites, and reduce excitatory synaptic events. The channels act to prevent large, rapid dendritic depolarizations, thereby regulating orthograde and retrograde propagation of dendritic potentials. |
| Document Type: Article |
| Language: English |
Addresses:
1. BAYLOR COLL MED, DEPT NEUROSCI, HOUSTON, TX 77030 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XG416 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |