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| Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11 |
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| Author(s): Reed P, Cucca F, Jenkins S, Merriman M, Wilson A, McKinney P, Bosi E, Joner G, Ronningen K, Thorsby E, Undlien D, Merriman T, Barnett A, Bain S, Todd J |
| Source: HUMAN MOLECULAR GENETICS Volume: 6 Issue: 7 Pages: 1011-1016 Published: JUL 1997 |
| Times Cited: 58 References: 27 |
| Abstract: A region of linkage to type 1 diabetes has been defined on human chromosome 10p11-q11 (IDDM10; P = 0.0007) using 236 UK and 76 US affected sibpairs and al cM resolution microsatellite marker map, Analysis by the transmission disequilibrium test (TDT) in 1159 families with at least one diabetic child, from the UK, the US, Norway, Sardinia and Italy provided additional support for linkage at D10S193 (P = 0.006, P-c = 0.17), Notably, 5.1 cM distal to D10S193, marker D10S588 also provided positive TDT results (P = 0.009, P-c = 0.25) but the allele under analysis was also preferentially transmitted to nonaffected siblings (P = 0.0008, P-c = 0.02), This allele was positively associated in an independent UK case control study and, importantly, was neutrally transmitted in control CEPH families, These results suggest a type 1 diabetes susceptibility locus on chromosome 10p11-q11 (provisionally designated IDDM10) and demonstrate the necessity of analysis of non affected siblings in disease families, as well as analysis of control families. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV OXFORD, NUFFIELD DEPT SURG, WELLCOME TRUST CTR HUMAN GENET, OXFORD OX3 7BN, ENGLAND
2. PAEDIAT EPIDEMIOL GRP, LEEDS LS3 9LN, W YORKSHIRE ENGLAND
3. UNIV MILAN, IST SCI SAN RAFFAELE, DEPT INTERNAL MED, MILAN, ITALY
4. AKER UNIV HOSP, AKER DIABET RES CTR, OSLO, NORWAY
5. NATL HOSP, INST TRANSPLANTAT IMMUNOL, OSLO, NORWAY
6. NATL INST PUBL HLTH, DEPT POPULAT HLTH SCI, N-0403 OSLO, NORWAY
7. UNIV BIRMINGHAM, BIRMINGHAM HEARTLANDS HOSP, DEPT MED DIABET ENDOCRINOL, BIRMINGHAM B9 5SS, W MIDLANDS ENGLAND |
| Publisher: OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Biochemistry & Molecular Biology; Genetics & Heredity |
| IDS Number: XH932 |
| ISSN: 0964-6906 |
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