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| Non-tunneled catheters for the collection and transplantation of peripheral blood stem cells in children |
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| Author(s): Madero L, Diaz MA, Benito A, Villa M, Valdivielso A |
| Source: BONE MARROW TRANSPLANTATION Volume: 20 Issue: 1 Pages: 53-56 Published: JUL 1997 |
| Times Cited: 13 References: 22 |
| Abstract: We analyzed the use of non-tunneled (polyurethane, double lumen) central venous catheters (CVCs) for the collection, conditioning, transplantation and immediate post-transplantation periods in 56 children with various malignant diseases, A total of 71 leukaphereses were performed, with a mean of 1.2 apheresis per patient, following administration of granulocyte colony-stimulating factor (G-CSF) using a continuous flow blood cell separator (Cobe Spectra), The mean TBV (total blood volume) processed was 4.5 +/- 1.2 s.d. (range 2.4-7), The mean flow rate was 30.6 ml/min and the duration of a single apheresis was 327 +/- 84 s.d. (range 175-511 min), The mean purities and efficacies of collections were 77.38 +/- s.d. (range 42-100) and 42.78 +/- s.d. (range 24-80), respectively, The mean numbers of mononuclear cells (MNC) and CD34(+) cells collected were 9.3 +/- 6.9 s.d. x 10(8)/kg (range 2-49) and 6.2 +/- 7.2 s.d. x 10(6)/kg (range 1-42), respectively, We observed the following complications during catheter insertion for collection: pneumothorax (1.7%), mechanical dysfunction (3.5%) that resolved with thrombolytic therapy, Complications during conditioning, transplantation and immediate post-transplantation periods were entry site infection in five patients (8.92%), catheter-related infection in two (3.57%) and catheter-related sepsis in three (5.35%), Our results indicate that the collection of PBSC with non-tunneled catheters is safe, effective and is associated with a low incidence of complications. |
| Document Type: Article |
| Language: English |
Addresses:
1. AUTONOMOUS UNIV MADRID, HOSP INFANTIL NINO JESUS, DEPT PEDIAT HEMATOL & ONCOL, E-28049 MADRID, SPAIN |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: XK233 |
| ISSN: 0268-3369 |
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