| | |  | | | | Record from Web of Science® | | | | | | |
| Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5 |
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| Author(s): Giannelli G, FalkMarzillier J, Schiraldi O, StetlerStevenson WG, Quaranta V |
| Source: SCIENCE Volume: 277 Issue: 5323 Pages: 225-228 Published: JUL 11 1997 |
| Times Cited: 655 References: 32 |
| Abstract: Structural changes in the extracellular matrix are necessary for cell migration during tissue remodeling and tumor invasion. Specific cleavage of laminin-5 (Ln-5) by matrix metalloprotease-2 (MMP2) was shown to induce migration of breast epithelial cells. MMP2 cleaved the Ln-5 gamma 2 subunit at residue 587, exposing a putative cryptic promigratory site on Ln-5 that triggers cell motility. This altered form of Ln-5 is found in tumors and in tissues undergoing remodeling, but not in quiescent tissues. Cleavage of Ln-5 by MMP2 and the resulting activation of the Ln-5 cryptic site may provide new targets for modulation of tumor cell invasion and tissue remodeling. |
| Document Type: Article |
| Language: English |
Addresses:
1. SCRIPPS RES INST, DEPT CELL BIOL, LA JOLLA, CA 92037 USA
2. UNIV BARI, INST MED CLIN 2, I-70124 BARI, ITALY
3. NCI, PATHOL LAB, BETHESDA, MD 20892 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XK418 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |