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| ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos |
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| Author(s): Page BD, Zhang W, Steward K, Blumenthal T, Priess JR |
| Source: GENES & DEVELOPMENT Volume: 11 Issue: 13 Pages: 1651-1661 Published: JUL 1 1997 |
| Times Cited: 54 References: 41 |
| Abstract: Epidermal cells are generated during Caenorhabditis elegans embryogenesis by several distinct lineage patterns. These patterns are controlled by maternal genes that determine the identities of early embryonic blastomeres. We show that the embryonically expressed gene elt-1, which was shown previously to encode a GATA-like transcription factor, is required for the production of epidermal cells by each of these lineages. Depending on their lineage history, cells that become epidermal in wild-type embryos become either neurons or muscle cells in elt-1 mutant embryos. The ELT-1 protein is expressed in epidermal cells and in their precursors. We propose that elt-1 functions at an early step in the specification of epidermal cell fates. |
| Document Type: Article |
| Language: English |
Addresses:
1. FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98109 USA
2. HOWARD HUGHES MED INST, SEATTLE, WA 98109 USA
3. INDIANA UNIV, DEPT BIOL, BLOOMINGTON, IN 47405 USA |
| Publisher: COLD SPRING HARBOR LAB PRESS, 1 BUNGTOWN RD, PLAINVIEW, NY 11724 |
| Subject Category: Cell Biology; Developmental Biology; Genetics & Heredity |
| IDS Number: XK995 |
| ISSN: 0890-9369 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |