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| 9,13-di-cis-retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90 |
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| Author(s): Imai S, Okuno M, Moriwaki H, Muto Y, Murakami K, Shudo K, Suzuki Y, Kojima S |
| Source: FEBS LETTERS Volume: 411 Issue: 1 Pages: 102-106 Published: JUL 7 1997 |
| Times Cited: 41 References: 28 |
| Abstract: We studied the mechanism by which 9,13-di-cis-retinoic acid (9,13dcRA), a novel and endogenous stereoisomer of all-trans-RA, induces TGF-beta formation in a human liver stellate cell line, LI90. 9,13dcRA induced the expression of RAR alpha and RAR beta, enhanced the production of tissue-type plasminogen activator (tPA), thereby, surface plasmin levels, and induced the activation of latent TGF-beta. Similar effects were obtained with RAR alpha-selective retinoid, but not with RAR beta- or RAR gamma-selective retinoid, and the induction was inhibited by RAR alpha-selective antagonist. These results suggest that 9,13dcRA up-regulates tPA expression, resulting in the formation of TGP-beta by LI90 cells, at least in part, via induction and activation of RAR alpha. (C) 1997 Federation of European Biochemical Societies. |
| Document Type: Article |
| Language: English |
Addresses:
1. RIKEN, INST PHYS & CHEM RES, TSUKUBA LIFE SCI CTR, LAB GENE TECHNOL & SAFETY, TSUKUBA, IBARAKI 305 JAPAN
2. GIFU UNIV, SCH MED, DEPT INTERNAL MED 1, GIFU 500, JAPAN
3. TOHOKU UNIV, SCH MED, DEPT PATHOL 1, AOBA KU, SENDAI, MIYAGI 980 JAPAN
4. UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: XL002 |
| ISSN: 0014-5793 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |