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| Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease |
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| Author(s): Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE |
| Source: SCIENCE Volume: 277 Issue: 5324 Pages: 373-376 Published: JUL 18 1997 |
| Times Cited: 271 References: 40 |
| Abstract: Most cases of early-onset familiar Alzheimer's disease (FAD) are caused by mutations in the genes encoding the presenilin 1 (PS1) and PS2 proteins, both of which undergo regulated endoproteolytic processing. During apoptosis, PS1 and PS2 were shown to be cleaved at sites distal to their normal cleavage sites by a caspase-3 family protease. In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer's disease. |
| Document Type: Article |
| Language: English |
Addresses:
1. HARVARD UNIV, SCH MED, MASSACHUSETTS GEN HOSP, DEPT NEUROL, GENET & AGING UNIT, CHARLESTOWN, MA 02129 USA
2. KWANGJU INST SCI & TECHNOL, DEPT LIFE SCI, KWANGJU, SOUTH KOREA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XL358 |
| ISSN: 0036-8075 |
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