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| Neandertal DNA sequences and the origin of modern humans |
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| Author(s): Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Paabo S |
| Source: CELL Volume: 90 Issue: 1 Pages: 19-30 Published: JUL 11 1997 |
| Times Cited: 513 References: 53 |
| Abstract: DNA was extracted from the Neandertal-type specimen found in 1856 in western Germany. By sequencing clones from short overlapping PCR products, a hitherto unknown mitochondrial (mt) DNA sequence was determined. Multiple controls indicate that this sequence is endogenous to the fossil. Sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, show that the Neandertal sequence falls outside the variation of modern humans. Furthermore, the age of the common ancestor of the Neandertal and modern human mtDNAs is estimated to be four times greater than that of the common ancestor of human mtDNAs. This suggests that Neandertals went extinct without contributing mtDNA to modern humans. |
| Document Type: Article |
| Language: English |
| Reprint Address: Krings, M (reprint author), UNIV MUNICH, INST ZOOL, POB 202136, D-80021 MUNICH, GERMANY |
Addresses:
1. PENN STATE UNIV, DEPT ANTHROPOL, STATE COLL, PA 16802 USA
2. RHEIN AMT BODENDENKMALPFLEGE, D-53115 BONN, GERMANY
3. HOHERE BERUFSFACHSCH PRAPARAT TECH ASSISTENTEN, D-44799 BOCHUM, GERMANY |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: XL362 |
| ISSN: 0092-8674 |
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