| | |  | | | | Record from Web of Science® | | | | | | |
| Bcl-2 and Bax function independently to regulate cell death |
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| Author(s): Knudson CM, Korsmeyer SJ |
| Source: NATURE GENETICS Volume: 16 Issue: 4 Pages: 358-363 Published: AUG 1997 |
| Times Cited: 268 References: 40 |
| Abstract: The BCL-2 family has Various pairs of antagonist and agonist proteins that regulate apoptosis, Whether their function is interdependent is uncertain. Using a genetic approach to address this question, we utilized gain- and loss-of-function models of Bcl-2 and Bax and found that apoptosis and thymic hypoplasia characteristic of Bcl-2-deficient mice are largely absent in mice also deficient in Bax. A single copy of Bax promoted apoptosis in the absence of Bcl-2. In contrast, overexpression of Bcl-2 still repressed apoptosis in the absence of Bax. While an in vivo competition exists between Bax and Bcl-2, each is able to regulate apoptosis independently. |
| Document Type: Article |
| Language: English |
Addresses:
1. WASHINGTON UNIV, SCH MED, HOWARD HUGHES MED INST, ST LOUIS, MO 63110 USA
2. WASHINGTON UNIV, SCH MED, DEPT MED, DIV MOL ONCOL, ST LOUIS, MO 63110 USA
3. WASHINGTON UNIV, SCH MED, DEPT PATHOL, DIV MOL ONCOL, ST LOUIS, MO 63110 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: XM909 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |