| | |  | | | | Record from Web of Science® | | | | | | |
| daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans |
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| Author(s): Kimura KD, Tissenbaum HA, Liu YX, Ruvkun G |
| Source: SCIENCE Volume: 277 Issue: 5328 Pages: 942-946 Published: AUG 15 1997 |
| Times Cited: 792 References: 44 |
| Abstract: A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor, Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity. |
| Document Type: Article |
| Language: English |
Addresses:
1. MASSACHUSETTS GEN HOSP, DEPT MOL BIOL, BOSTON, MA 02114 USA
2. HARVARD UNIV, SCH MED, DEPT GENET, BOSTON, MA 02114 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XQ985 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |