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| Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine |
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| Author(s): Jentsch JD, Redmond DE, Elsworth JD, Taylor JR, Youngren KD, Roth RH |
| Source: SCIENCE Volume: 277 Issue: 5328 Pages: 953-955 Published: AUG 15 1997 |
| Times Cited: 195 References: 45 |
| Abstract: The effects of the psychotomimetic drug phencyclidine on the neurochemistry and function of the prefrontal cortex in vervet monkeys were investigated, Monkeys treated with phencyclidine twice a day for 14 days displayed performance deficits on a task that was sensitive to prefrontal cortex function; the deficits were ameliorated by the atypical antipsychotic drug clozapine, Repeated exposure to phencyclidine caused a reduction in both basal and evoked dopamine utilization in the dorsolateral prefrontal cortex, a brain region that has long been associated with cognitive function, Behavioral deficits and decreased dopamine utilization remained after phencyclidine treatment was stopped, an indication that these effects were not simply due to direct drug effects. The data suggest that repeated administration of phencyclidine in monkeys may be useful for studying psychiatric disorders associated with cognitive dysfunction and dopamine hypofunction in the prefrontal cortex, particularly schizophrenia. |
| Document Type: Article |
| Language: English |
Addresses:
1. YALE UNIV, SCH MED, DEPT PSYCHIAT, NEW HAVEN, CT 06520 USA
2. YALE UNIV, SCH MED, DEPT PHARMACOL, NEW HAVEN, CT USA
3. YALE UNIV, SCH MED, NEUROBIOL SECT, NEW HAVEN, CT USA
4. YALE UNIV, SCH MED, DEPT NEUROSURG, NEW HAVEN, CT USA
5. YALE UNIV, SCH MED, INTERDEPT NEUROSCI PROGRAM, NEW HAVEN, CT USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XQ985 |
| ISSN: 0036-8075 |
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