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| AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer |
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| Author(s): Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS |
| Source: SCIENCE Volume: 277 Issue: 5328 Pages: 965-968 Published: AUG 15 1997 |
| Times Cited: 967 References: 21 |
| Abstract: Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen-dependent transcription, These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers. |
| Document Type: Article |
| Language: English |
Addresses:
1. NATL HUMAN GENOME RES INST, CANC GENET LAB, NIH, BETHESDA, MD 20892 USA
2. UNIV TAMPERE, INST MED TECHNOL, CANC GENET LAB, FIN-33101 TAMPERE, FINLAND
3. TAMPERE UNIV HOSP, FIN-33101 TAMPERE, FINLAND
4. UNIV BASEL, INST PATHOL, CH-4003 BASEL, SWITZERLAND |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XQ985 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |