| | |  | | | | Record from Web of Science® | | | | | | |
| Co-receptors for HIV-1 entry |
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| Author(s): Moore JP |
| Source: CURRENT OPINION IN IMMUNOLOGY Volume: 9 Issue: 4 Pages: 551-562 Published: AUG 1997 |
| Times Cited: 346 References: 93 |
| Abstract: HIV-1 enters its target cells by fusion at the plasma membrane. The primary cellular receptor for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the necessary entry co-factors (co-receptors or second receptors) were identified as being members of the seven-transmembrane-spanning receptor family fusin: CXCR4 for T-tropic strains and CCR5, principally, for M-tropic strains. The co-receptor functions of these proteins are inhibited by their natural alpha- and beta-chemokine ligands. |
| Document Type: Review |
| Language: English |
| Reprint Address: Moore, JP (reprint author), ROCKEFELLER UNIV, AARON DIAMOND AIDS RES CTR, 455 1ST AVE, NEW YORK, NY 10021 USA |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Immunology |
| IDS Number: XT719 |
| ISSN: 0952-7915 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |