| | |  | | | | Record from Web of Science® | | | | | | |
| Cell-cycle arrest versus cell death in cancer therapy |
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| Author(s): Waldman T, Zhang YG, Dillehay L, Yu J, Kinzler K, Vogelstein B, Williams J |
| Source: NATURE MEDICINE Volume: 3 Issue: 9 Pages: 1034-1036 Published: SEP 1997 |
| Times Cited: 271 References: 17 |
| Abstract: In response to anticancer therapeutics, human colon cancer cells growing in vitro either enter into a stable arrest or die, depending on the integrity of their cell-cycle checkpoints(1). To test whether altered checkpoints can modulate sensitivity to treatment in vivo, xenografts were established from isogenic lines differing only in their p21 checkpoint status. Although all tumors with intact checkpoint function underwent regrowth after treatment with gamma-radiation, a significant fraction of checkpoint-deficient tumors were completely cured. This difference in sensitivity was not detected by the clonogenic survival assay, because both arrest and death preclude outgrowth of colonies. These results demonstrate that checkpoint status affects sensitivity to anticancer treatments in vivo, and these findings have important implications for identifying and testing new therapeutic compounds. |
| Document Type: Article |
| Language: English |
| Reprint Address: Waldman, T (reprint author), JOHNS HOPKINS UNIV, SCH MED, JOHNS HOPKINS ONCOL CTR, 424 N BOND ST, BALTIMORE, MD 21231 USA |
Addresses:
1. PROGRAM HUMAN GENET, BALTIMORE, MD 21231 USA
2. JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, BALTIMORE, MD 21231 USA
3. JOHNS HOPKINS UNIV, SCH MED, JOHNS HOPKINS ONCOL CTR, RADIOBIOL LAB, BALTIMORE, MD 21287 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: XT842 |
| ISSN: 1078-8956 |
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