| | |  | | | | Record from Web of Science® | | | | | | |
| Functions of mammalian Polycomb group and trithorax group related genes |
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| Author(s): Gould A |
| Source: CURRENT OPINION IN GENETICS & DEVELOPMENT Volume: 7 Issue: 4 Pages: 488-494 Published: AUG 1997 |
| Times Cited: 137 References: 61 |
| Abstract: Genes of the Polycomb and trithorax groups (PcG and trxG) are part of a cellular memory system that maintains inactive and active states of homeotic gene expression in Drosophila. Recent genetic evidence indicates that several related loci in mammals are also involved in the regulation of Hox genes. Like their Drosophila counterparts, the vertebrate gene products are components of multiprotein complexes that regulate transcriptional activation repression and aspects of chromatin structure, Initial indications suggest the existence of a large mammalian PcG and trxG family, with a potential to encode multiple specialised functions in cell late and cell-cycle control. |
| Document Type: Article |
| Language: English |
| Reprint Address: Gould, A (reprint author), NATL INST MED RES, MRC, MILL HILL, LONDON NW7 1AA, ENGLAND |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Cell Biology; Genetics & Heredity |
| IDS Number: XU025 |
| ISSN: 0959-437X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |