| | |  | | | | Record from Web of Science® | | | | | | |
| Evolutionary origins and maintenance of redundant gene expression during metazoan development |
|
|
| Author(s): Cooke J, Nowak MA, Boerlijst M, MaynardSmith J |
| Source: TRENDS IN GENETICS Volume: 13 Issue: 9 Pages: 360-364 Published: SEP 1997 |
| Times Cited: 110 References: 43 |
| Abstract: Various levels of redundancy in developmental gene function appear common in complex metazoans. There might be no apparent phenotype at many, or even any, of a gene's specific expression sites in homozygous null mutant embryos. Here we ask what underlies the origin of such arrangements. The generation of families of genes by duplication has clearly been important. Additionally, however, selection might have driven molecularly unrelated genes, which encode proteins of similar physiological function, to become expressed during the same sets of development events (times and places), even though each such gene might initially have evolved in connection with just one of these events. |
| Document Type: Review |
| Language: English |
| Reprint Address: Cooke, J (reprint author), NATL INST MED RES, DIV DEV NEUROBIOL, RIDGEWAY, MILL HILL, LONDON NW7 1AA, ENGLAND |
Addresses:
1. DEPT ZOOL, OXFORD OX1 3P, ENGLAND
2. UNIV SUSSEX, SCH BIOL SCI, BRIGHTON BN1 9QG, E SUSSEX ENGLAND |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: XU045 |
| ISSN: 0168-9525 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |